Filming of season two took place in Toronto, Cambridge, and St. George in Ontario, in Drumheller, Alberta and near Vancouver, British Columbia where they made use of the old set of Bordertown.
May 1896, Murdoch creates a device he calls Daylight in a Box. The following month, Crabtree finds a curious device in Murdoch’s office, which appears to be a small strip of paper that “sticks” on one side and not on the other. Crabtree suggests Murdoch call it “Constable Crabtree’s Household Adhesive Strips.”
Murdoch uses cutting edge technology involving x-rays to debunk certain claims made during a murder investigation involving dinosaur bones.
When Buffalo Bill Cody's Western Extravaganza pulls into town, murder follows closely behind. As Murdoch investigates the death of a cowboy who has a dark past, Inspector Brackenreid finds himself tempted by the legendary Annie Oakley.
Murdoch finds himself teamed with a Scotland Yard Investigator who thinks the serial killer they're pursuing may be none other than Jack the Ripper. Murdoch invites Dr. Ogden to an up-coming ball, and to prepare for it, dancing lessons are the order of the day.
A young woman dies mysteriously while seeking medical attention. While investigating the mysterious death of a young woman, Murdoch and Dr. Ogden find themselves on opposite sides of the thorny issue of abortion
As Murdoch investigates the seemingly perfect murder of a university professor, he realizes his relationship with Dr. Ogden has been seriously harmed. Meanwhile, Constable Crabtree's search for his biological mother turns up not one, but two candidates for the job.
A savage murder, seemingly at the jaws of a wild beast, leads Murdoch into the mysterious world of North American shamanism and lycanthropy. While searching for a rational explanation, Murdoch is forced to choose between Enid and Dr. Ogden.
While investigating a murder, Murdoch finds himself teamed with a North West Mounted Policeman whose methods and mannerisms are strikingly similar to his own - perhaps too similar? Murdoch hopes to rekindle his relationship with Dr. Ogden - but is it too late?