Burrit Greyson operated the Greyson Institute where the brains of "subjects", as distinguished by Greyson from "patients", were analyzed.
During Detective William Murdoch's investigation into the murder of Dr. Francis Grout, it came to light that Greyson had once worked with a subject called Sophia Chaucer. Chaucer suffered from epilepsy. Greyson performed an untested and radical surgery on her brain in hopes of helping her but instead he damaged her brain. Chaucer was left without any memory whatsoever.